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HyenaDNA Long Range Sequence Modeling at Single Nucleotide Resolution

Neural Information Processing Systems

Similar to natural language models, researchers have proposed foundation models in genomics to learn generalizable features from unlabeled genome data that can then be fine-tuned for downstream tasks such as identifying regulatory elements. Due to the quadratic scaling of attention, previous Transformer-based genomic models have used 512 to 4k tokens as context (<0.001% of the human genome), significantly limiting the modeling of long-range interactions in DNA. In addition, these methods rely on tokenizers or fixed k-mers to aggregate meaningful DNA units, losing single nucleotide resolution (i.e. DNA "characters") where subtle genetic variations can completely alter protein function via single nucleotide polymorphisms (SNPs). Recently, Hyena, a large language model based on implicit convolutions was shown to match attention in quality while allowing longer context lengths and lower time complexity.



DeepSeek promises its new AI model has 'world-class' reasoning

Engadget

DeepSeek promises its new AI model has'world-class' reasoning The new models give users access to a'cost effective 1 million context length.' DeepSeek has released its latest AI models, the V4 Pro and Flash versions, a bit over a year after it went viral and became the top rated free app on Apple's App Store in the US. "Welcome to the era of cost-effective 1 million context length," DeepSeek said in its announcement . Context length is what you call the maximum number of tokens that an AI model can remember, so the bigger it is, the more coherent and consistent an AI is when it comes to extended conversations. OpenAI's recently announced GPT 5.5 has a context window ranging from 400,000 to 1 million, for instance.


In-Place Test-Time Training

arXiv.org Machine Learning

The static ``train then deploy" paradigm fundamentally limits Large Language Models (LLMs) from dynamically adapting their weights in response to continuous streams of new information inherent in real-world tasks. Test-Time Training (TTT) offers a compelling alternative by updating a subset of model parameters (fast weights) at inference time, yet its potential in the current LLM ecosystem is hindered by critical barriers including architectural incompatibility, computational inefficiency and misaligned fast weight objectives for language modeling. In this work, we introduce In-Place Test-Time Training (In-Place TTT), a framework that seamlessly endows LLMs with Test-Time Training ability. In-Place TTT treats the final projection matrix of the ubiquitous MLP blocks as its adaptable fast weights, enabling a ``drop-in" enhancement for LLMs without costly retraining from scratch. Furthermore, we replace TTT's generic reconstruction objective with a tailored, theoretically-grounded objective explicitly aligned with the Next-Token-Prediction task governing autoregressive language modeling. This principled objective, combined with an efficient chunk-wise update mechanism, results in a highly scalable algorithm compatible with context parallelism. Extensive experiments validate our framework's effectiveness: as an in-place enhancement, it enables a 4B-parameter model to achieve superior performance on tasks with contexts up to 128k, and when pretrained from scratch, it consistently outperforms competitive TTT-related approaches. Ablation study results further provide deeper insights on our design choices. Collectively, our results establish In-Place TTT as a promising step towards a paradigm of continual learning in LLMs.


Base of RoPE Bounds Context Length

Neural Information Processing Systems

Position embedding is a core component of current Large Language Models (LLMs). Rotary position embedding (RoPE), a technique that encodes the position information with a rotation matrix, has been the de facto choice for position embedding in many LLMs, such as the Llama series. RoPE has been further utilized to extend long context capability, which is roughly based on adjusting the \textit{base} parameter of RoPE to mitigate out-of-distribution (OOD) problems in position embedding. However, in this paper, we find that LLMs may obtain a superficial long-context ability based on the OOD theory. We revisit the role of RoPE in LLMs and propose a novel property of long-term decay, we derive that the \textit{base of RoPE bounds context length}: there is an absolute lower bound for the base value to obtain certain context length capability. Our work reveals the relationship between context length and RoPE base both theoretically and empirically, which may shed light on future long context training.


Balancing Context Length and Mixing Times for Reinforcement Learning at Scale

Neural Information Processing Systems

Due to the recent remarkable advances in artificial intelligence, researchers have begun to consider challenging learning problems such as learning to generalize behavior from large offline datasets or learning online in non-Markovian environments. Meanwhile, recent advances in both of these areas have increasingly relied on conditioning policies on large context lengths. A natural question is if there is a limit to the performance benefits of increasing the context length if the computation needed is available. In this work, we establish a novel theoretical result that links the context length of a policy to the time needed to reliably evaluate its performance (i.e., its mixing time) in large scale partially observable reinforcement learning environments that exhibit latent sub-task structure. This analysis underscores a key tradeoff: when we extend the context length, our policy can more effectively model non-Markovian dependencies, but this comes at the cost of potentially slower policy evaluation and as a result slower downstream learning. Moreover, our empirical results highlight the relevance of this analysis when leveraging Transformer based neural networks. This perspective will become increasingly pertinent as the field scales towards larger and more realistic environments, opening up a number of potential future directions for improving the way we design learning agents.


An Efficient Recipe for Long Context Extension via Middle-Focused Positional Encoding

Neural Information Processing Systems

Recently, many methods have been developed to extend the context length of pre-trained large language models (LLMs), but they often require fine-tuning at the target length ($\gg4K$) and struggle to effectively utilize information from the middle part of the context.


You Only Cache Once: Decoder-Decoder Architectures for Language Models

Neural Information Processing Systems

We introduce a decoder-decoder architecture, YOCO, for large language models, which only caches key-value pairs once. It consists of two components, i.e., a cross-decoder stacked upon a self-decoder. The self-decoder efficiently encodes global key-value (KV) caches that are reused by the cross-decoder via cross-attention. The overall model behaves like a decoder-only Transformer, although YOCO only caches once. The design substantially reduces GPU memory demands, yet retains global attention capability. Additionally, the computation flow enables prefilling to early exit without changing the final output, thereby significantly speeding up the prefill stage. Experimental results demonstrate that YOCO achieves favorable performance compared to Transformer in various settings of scaling up model size and number of training tokens. We also extend YOCO to 1M context length with near-perfect needle retrieval accuracy. The profiling results show that YOCO improves inference memory, prefill latency, and throughput by orders of magnitude across context lengths and model sizes.


GV-Rep: A Large-Scale Dataset for Genetic Variant Representation Learning

Neural Information Processing Systems

The development of deep learning approaches for modeling these multifactorial effects of GVs is still in its nascent stages, primarily due to the lack of comprehensive datasets that capture the intricate relationships between GVs and their downstream effects on complex traits.


Many-shot Jailbreaking

Neural Information Processing Systems

Longer contexts present a new attack surface for adversarial attacks. In search of a "fruit-fly" of long-context vulnerabilities, we study Many-shot Jailbreaking (MSJ; Figure 1), a simple yet effective and scalable jailbreak.